Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

Rucinskaite, Gabriele and Thompson, Sebastian A. and Paterson, Sureyya and De La Rica, Roberto (2017) Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose. Nanoscale, 9 (17). pp. 5404-5407. ISSN 2040-3372 (https://doi.org/10.1039/c7nr00298j)

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Abstract

A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide-integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).

ORCID iDs

Rucinskaite, Gabriele, Thompson, Sebastian A., Paterson, Sureyya ORCID logoORCID: https://orcid.org/0000-0001-5433-7811 and De La Rica, Roberto;
CORE (COnnecting REpositories)