Correction to "Modular, step-efficient palladium-catalyzed cross-coupling strategy to access C6-heteroaryl 2-aminopurine ribonucleosides"
Buchanan, Helena S. and Pauff, Steven M. and Kosmidis, Tilemachos D. and Taladriz-Sender, Andrea and Rutherford, Olivia I. and Hatit, Marine Z. C. and Fenner, Sabine and Watson, Allan J. B. and Burley, Glenn A. (2017) Correction to "Modular, step-efficient palladium-catalyzed cross-coupling strategy to access C6-heteroaryl 2-aminopurine ribonucleosides". Organic Letters, 19 (14). ISSN 1523-7060
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Text (Buchanan-etal-OL-2017-Correction-to-modular-step-efficient-palladium-catalyzed-cross-coupling-strategy)
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Abstract
Two Pd-catalyzed methods to access 6-heteroaryl 2-aminopurine ribonucleosides from 6-chloroguanosine are described. First, Pd-132-catalyzed Suzuki-Miyaura cross-coupling using a series of boron substrates and 6-chloroguanosine forms 6-heteroaryl-2-aminopurines in a single step. The versatility of 6-chloroguanosine is further demonstrated using a modified Sonogashira coupling employing potassium iodide as an additive. Finally, the utility of the 6-alkynyl-2-aminopurine ribonucleoside as a dipolarophile in [3 + 2] cycloadditions is presented, affording triazoles and isoxazoles when reacted with azide and isonitrile 1,3-dipoles, respectively.
Creators(s): |
Buchanan, Helena S. ![]() ![]() ![]() ![]() ![]() ![]() | Item type: | Article |
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ID code: | 61590 |
Keywords: | boron substrates, Sonogashira coupling, Suzuki−Miyaura cross coupling, ribonucleosides, Chemistry, Organic Chemistry |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 16 Aug 2017 14:32 |
Last modified: | 08 Feb 2021 03:40 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/61590 |
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