Can parasitic worms cure the modern world's ills?

Harnett, Margaret M. and Harnett, William (2017) Can parasitic worms cure the modern world's ills? Trends in Parasitology. ISSN 1471-4922

[img] Text (Harnett-Harnett-TP2017-Can-parasitic-worms-cure-the-modern-world's-ills)
Harnett_Harnett_TP2017_Can_parasitic_worms_cure_the_modern_world_s_ills.doc
Accepted Author Manuscript
Download (949kB)

    Abstract

    There has been increasing recognition that the alarming surge in allergy and autoimmunity in the industrialised and developing worlds shadows the rapid eradication of pathogens, such as parasitic helminths. Appreciation of this has fuelled an explosion in research investigating the therapeutic potential of these worms. This review considers the current state-of-play with a particular focus on exciting recent advances in the identification of potential novel targets for immunomodulation that can be exploited therapeutically. Furthermore, we contemplate the prospects for designing worm-derived immunotherapies for an ever-widening range of inflammatory diseases, including, for example, obesity, cardiovascular disease, and ageing as well as neurodevelopmental disorders like autism.

    Author(s):Harnett, Margaret M. and Harnett, William ORCID logoORCID: https://orcid.org/0000-0001-9545-9401
    Item type:Article
    ID code:61472
    Keywords:helminth, drug development, immunomodulation, Microbiology, Infectious Diseases, Parasitology
    Subjects:Science > Microbiology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:03 Aug 2017 15:41
    Last modified:15 Nov 2019 05:57
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/61472
    Export data:
    CORE (COnnecting REpositories)