Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells
Laté de Laté, Perle and Pineda, Miguel and Harnett, Margaret and Harnett, William and Besteiro, Sébastien and Langsley, Gordon (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomedical Journal, 40 (1). pp. 23-30. ISSN 2320-2890 (https://doi.org/10.1016/j.bj.2017.01.001)
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Abstract
Apicomplexan parasites are responsible for a number of important human pathologies. Obviously, as Eukaryotes they share a number of cellular features and pathways with their respective host cells. One of them is autophagy, a process involved in the degradation of the cell's own components. These intracellular parasites nonetheless seem to present a number of original features compared to their very evolutionarily distant host cells. In mammals and other metazoans, autophagy has been identified as an important contributor to the defence against microbial pathogens. Thus, host autophagy also likely plays a key role in the control of apicomplexan parasites, although its potential manipulation and subversion by intracellular parasites creates a complex interplay in the regulation of host and parasite autophagy. In this mini-review, we summarise current knowledge on autophagy in both parasites and their host cells, in the context of infection by three Apicomplexa: Plasmodium, Toxoplasma, and Theileria.
ORCID iDs
Laté de Laté, Perle, Pineda, Miguel, Harnett, Margaret, Harnett, William ORCID: https://orcid.org/0000-0001-9545-9401, Besteiro, Sébastien and Langsley, Gordon;-
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Item type: Article ID code: 60576 Dates: DateEvent28 February 2017Published11 January 2017AcceptedSubjects: Science > Microbiology Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 03 May 2017 11:11 Last modified: 23 Oct 2024 00:24 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/60576