Excitatory microcircuits within superficial layers of the medial entorhinal cortex

Winterer, Jochen and Maier, Nikolaus and Wozny, Christian and Beed, Prateep and Breustedt, Jörg and Evangelista, Roberta and Peng, Yangfan and D'Albis, Tiziano and Kempter, Richard and Schmitz, Dietmar (2017) Excitatory microcircuits within superficial layers of the medial entorhinal cortex. Cell Reports, 19 (6). pp. 1110-1116. ISSN 2211-1247

[img]
Preview
 Text (Winterer-etal-CR-2017-Excitatory-microcircuits-within-superficial-layers-of-the-medial-entorhinal)
Winterer_etal_CR_2017_Excitatory_microcircuits_within_superficial_layers_of_the_medial_entorhinal.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (3MB)| Preview

    Abstract

    The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depends on the local microcircuitry. However, local networks within the MEC are still not sufficiently characterized. Here, applying up to eight simultaneous whole-cell recordings in acute brain slices, we demonstrate the existence of unitary excitatory connections between principal neurons in the superficial layers of the MEC. In particular, we find prevalent feed-forward excitation from pyramidal neurons in layer III and layer II onto stellate cells in layer II, which might contribute to the generation or the inheritance of grid-cell patterns.

    Author(s):Winterer, Jochen, Maier, Nikolaus, Wozny, Christian ORCID logoORCID: https://orcid.org/0000-0003-4220-2033, Beed, Prateep, Breustedt, Jörg, Evangelista, Roberta, Peng, Yangfan, D'Albis, Tiziano, Kempter, Richard and Schmitz, Dietmar
    Item type:Article
    ID code:60502
    Keywords:cell connectivity, cell grid patterns, medial entorhinal cortex, Pharmacy and materia medica, Pharmacology, Toxicology and Pharmaceutics(all)
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:24 Apr 2017 10:14
    Last modified:11 Oct 2019 02:04
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/60502
    Export data:
    CORE (COnnecting REpositories)