Transition-metal-free amine oxidation : a chemoselective strategy for the late-stage formation of lactams
Griffiths, Robert J. and Burley, Glenn A. and Talbot, Eric P.A. (2017) Transition-metal-free amine oxidation : a chemoselective strategy for the late-stage formation of lactams. Organic Letters, 19 (4). pp. 870-873. ISSN 1523-7060 (https://doi.org/10.1021/acs.orglett.7b00021)
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Abstract
A metal-free strategy for the formation of lactams via selective oxidation of cyclic secondary and tertiary amines is described. Molecular iodine facilitates both chemoselective and regioselective oxidation of C–H bonds directly adjacent to a cyclic amine. The mild conditions, functional group tolerance, and substrate scope are demonstrated using a suite of diverse small molecule cyclic amines, including clinically approved drug scaffolds.
ORCID iDs
Griffiths, Robert J. ORCID: https://orcid.org/0000-0002-5692-4275, Burley, Glenn A. and Talbot, Eric P.A.;-
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Item type: Article ID code: 60151 Dates: DateEvent8 February 2017Published8 February 2017AcceptedNotes: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.orglett.7b00021. Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 13 Mar 2017 12:26 Last modified: 26 Sep 2024 00:42 URI: https://strathprints.strath.ac.uk/id/eprint/60151