Reversible DNA micro-patterning using the fluorous effect

Flynn, Gabriella and Withers, Jamie and Macias, Gerard and Sperlin, Justin R. and Henry, Sarah L. and Cooper, Jonathan M. and Burley, Glenn A. and Clark, Alasdair W. (2017) Reversible DNA micro-patterning using the fluorous effect. Chemical Communications, 53 (21). pp. 3094-3097. ISSN 1359-7345 (

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We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences.