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Strathprints makes available scholarly Open Access content by the Fraser of Allander Institute (FAI), a leading independent economic research unit focused on the Scottish economy and based within the Department of Economics. The FAI focuses on research exploring economics and its role within sustainable growth policy, fiscal analysis, energy and climate change, labour market trends, inclusive growth and wellbeing.

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An investigation into the immunogenicity of a GnRH analogue in male rats : a comparison of the toxicity of various adjuvants used in conjunction with GnRH-glycys

Ferro, V. A. and O'Grady, J E and Notman, J and Stimson, W H (1996) An investigation into the immunogenicity of a GnRH analogue in male rats : a comparison of the toxicity of various adjuvants used in conjunction with GnRH-glycys. Vaccine, 14 (5). pp. 451-457. ISSN 0264-410X

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Abstract

Immunization of male Copenhagen Fischer rats with a gonadotrophin releasing hormone (GnRH) analogue, conjugated to PPD resulted in high levels of antibody being produced which disrupted gonadal function in male rats. The antibody reduced serum testosterone levels and subsequently suppressed spermatogenesis. Alternatives to Freund's adjuvant were tested, namely, aluminium hydroxide and non-ionic surfactant vesicles (NISV). The study showed that aluminium hydroxide was as effective as Freund's adjuvant and less toxic, in both BCG and non-BCG primed animals. However, NISV were completely non-toxic and most effective in conjunction with BCG priming. The data obtained showed that NISV have the potential to be used as an alternative to FCA and aluminium hydroxide-based adjuvants.