Adverse effects of carbamazepine monotherapy among patients in Nigeria : a pilot study and implications

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Olusanya, Adedunni and Ogunleye, Olayinka and Godman, Brian and Fadare, Joseph and Danesi, Mustafa (2017) Adverse effects of carbamazepine monotherapy among patients in Nigeria : a pilot study and implications. Journal of Comparative Effectiveness Research, 6 (1). pp. 33-42. ISSN 2042-6313 (https://doi.org/10.2217/cer-2016-0057)

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Abstract

AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients.  METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors.  RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects.  CONCLUSION: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

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