The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme : a two centre observational study

Munro, Ami and Gillespie, Colette and Cotton, Seonaidh and Busby-Earle, Camille and Kavanagh, Kimberley and Cuschieri, Kate and Cubie, Heather and Robertson, Chris and Smart, Louise and Pollock, Kevin and Moore, Catherine and Palmer, Timothy and Cruickshank, Margaret E (2017) The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme : a two centre observational study. BJOG: An International Journal of Obstetrics and Gynaecology, 124 (9). pp. 1394-1401. ISSN 1470-0328 (https://doi.org/10.1111/1471-0528.14563)

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Abstract

Objective To determine if HPV immunisation has affected the prevalence of HPV genotypes and colposcopic features of CIN in young women referred for colposcopy. Design A two-centre observational study including vaccinated and unvaccinated women. Setting Colposcopy clinics serving two health regions in Scotland, UK. Population 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening. Methods Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features. Main outcome measures Colposcopic features, HPV genotypes, mRNA expression and cervical histology. Results The prevalence of HPV 16 was significantly lower in the vaccinated (8.6%) compared with the unvaccinated (46.7%) group (p=0.001). The number of cases of cervical intraepithelial neoplasia 2 or more (CIN2+) was significantly lower in vaccinated women (p=0.006).HPV vaccine did not have a statistically significant effect on commonly recognised colposcopic features but there was a slight reduction in the positive predictive value (PPV) of colposcopy for CIN2+ from 74% (unvaccinated) to 66.7% (vaccinated). Conclusions In this group of young women with abnormal cytology referred to colposcopy, HPV vaccination via a catch-up programme reduced the prevalence of CIN2+ and HPV 16 infection. The reduced PPV of colposcopy for the detection of CIN2+ in vaccinated women is at the lower acceptable level of the UK national cervical screening programme guidelines.

ORCID iDs

Munro, Ami, Gillespie, Colette, Cotton, Seonaidh, Busby-Earle, Camille, Kavanagh, Kimberley ORCID logoORCID: https://orcid.org/0000-0002-2679-5409, Cuschieri, Kate, Cubie, Heather, Robertson, Chris, Smart, Louise, Pollock, Kevin, Moore, Catherine, Palmer, Timothy and Cruickshank, Margaret E;
  • Item type:Article
    ID code:59430
    Dates:
    Date
    Event
    1 August 2017
    Published
    20 July 2017
    Published Online
    11 January 2017
    Accepted
    Notes:© 2017 Royal College of Obstetricians and Gynaecologists This is the peer reviewed version of the following article: Munro, A., Gillespie, C., Cotton, S., Busby-Earle, C., Kavanagh, K., Cuschieri, K., ... Cruickshank, M. E. (2017). The impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study. BJOG: An International Journal of Obstetrics and Gynaecology, which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving Munro A, Gillespie C, Cotton S, Busby-Earle C, Kavanagh K, Cuschieri K, Cubie H, Robertson C, Smart L, Pollock K, Moore C, Palmer T, Cruickshank ME. The impact of human papillomavirus (HPV) type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two-centre observational study. BJOG 2017; 124: 1394–1401.
    Subjects:Medicine > Gynecology and obstetrics
    Department:Faculty of Science > Mathematics and Statistics
    Strategic Research Themes > Health and Wellbeing
    Depositing user: Pure Administrator
    Date deposited:13 Jan 2017 14:23
    Last modified:11 Nov 2024 11:36
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/59430
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