Rheological behaviour of vitreous humour

Silva, Andreia F. and Alves, Manuel A. and Oliveira, Monica S. N. (2017) Rheological behaviour of vitreous humour. Rheologica Acta. pp. 1-21. ISSN 1435-1528

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    Abstract

    The vitreous humour (VH) is a complex biofluid that occupies a large portion of the eyeball between the lens and the retina, and exhibits non-Newtonian rheological properties that are key for its function in the eye. It is often possible to distinguish two different phases in VH, known as liquid and gel phases (Sebag, 1987). In this work, we present a detailed rheological characterisation of the two phases of the VH under shear and extensional flow conditions. Healthy New Zealand rabbit eyes were used to measure the surface tension and the shear and extensional rheological properties of VH in different phase conformations and at different times after dissection. The results show that VH liquid phase exhibits a surface tension of 47.8 mN/m, a shear thinning behaviour reaching a viscosity plateau around 10-3 Pa.s for shear rates above 1000 s-1, and an average relaxation time of 9.7 ms in extensional flow. Interestingly, both VH phases present higher storage modulus than loss modulus and the measurements performed with VH gel phase 4±1 hours after dissection exhibit the highest moduli values. The compliance measurements for the gel phase show a viscoelastic gel behaviour and that compliance values decrease substantially with time after dissection. Our results show that the two VH phases exhibit viscoelastic behaviour, but with distinct rheological characteristics, consistent with a gel phase mostly composed of collagen entangled by hyaluronan and a second phase mainly composed of hyaluronan in aqueous solution.

    Author(s):Silva, Andreia F. ORCID logoORCID: https://orcid.org/0000-0002-5142-2276, Alves, Manuel A. and Oliveira, Monica S. N. ORCID logoORCID: https://orcid.org/0000-0002-1836-4692
    Item type:Article
    ID code:59427
    Keywords:vitreous humour, biorheology, biofluid, rheology, Mechanical engineering and machinery, Physics, Biomedical Engineering, Mechanical Engineering, Condensed Matter Physics
    Subjects:Technology > Mechanical engineering and machinery
    Science > Physics
    Department:Faculty of Engineering > Mechanical and Aerospace Engineering
    Technology and Innovation Centre > Advanced Engineering and Manufacturing
    Depositing user: Pure Administrator
    Date deposited:13 Jan 2017 12:15
    Last modified:16 Jan 2020 23:49
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/59427
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