Non-equilibrium cobalt(iii) "click" capsules

Symmers, P. R. and Burke, M. J. and August, D. P. and Thomson, P. I T and Nichol, G. S. and Warren, M. R. and Campbell, C. J. and Lusby, P. J. (2014) Non-equilibrium cobalt(iii) "click" capsules. Chemical Science, 6 (1). pp. 756-760. ISSN 2041-6539 (

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Cobalt(III) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt(II) precursor and a readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in a non-equilibrium state. A preliminary investigation into the host–guest chemistry of a water-soluble derivative shows it can bind and differentiate a range of different neutral organic molecules. The stability of this ensemble also permits the study of guest-binding at high salt concentrations.