Towards the total synthesis of agariblazeispirol C
Kerr, William and Paterson, Laura and Sutherland, Andrew J. (2010) Towards the total synthesis of agariblazeispirol C. In: 240th ACS National Meeting & Exposition, 2010-08-22 - 2010-08-26, Boston Convention & Exhibition Center. (http://acselb-529643017.us-west-2.elb.amazonaws.co...)
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Efforts within our laboratory have focused towards the synthesis of Agariblazeispirol C, 1, which was recently isolated from the cultured mycelia of Agaricus blazei. Our proposed pathway for gaining access to Agariblazeispirol C centres on the strategic employment of metal-mediated cyclisation chemistry. Specifically, an intramolecular Pauson-Khand reaction (PKR) will be used to construct the C/D ring section of the natural target, and a novel intramolecular Heck reaction will establish the key all carbon quaternary centre between rings B and C.
ORCID iDs
Kerr, William ORCID: https://orcid.org/0000-0002-1332-785X, Paterson, Laura and Sutherland, Andrew J.;-
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Item type: Conference or Workshop Item(Speech) ID code: 58040 Dates: DateEvent22 August 2010PublishedKeywords: total synthesis, agariblazeispirol C, Agaricus blazei, metal-mediated cyclisation , Pauson-Khand reaction, Heck reaction, Chemistry, Organic Chemistry Subjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 04 Oct 2016 11:27 Last modified: 18 Jan 2023 13:19 URI: https://strathprints.strath.ac.uk/id/eprint/58040