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Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination

AlHusban, Farhan and Elshaer, Amr M. and Kansara, Jiteen H. and Smith, Alan M. and Grover, Liam M. and Perrie, Yvonne and Mohammed, Afzal-Ur-Rahman (2010) Investigation of formulation and process of lyophilised orally disintegrating tablet (ODT) using novel amino acid combination. Pharmaceutics, 2 (1). pp. 1-17. ISSN 1999-4923

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Abstract

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of chronic illnesses. The current study demonstrates the feasibility of using combination of proline and serine to formulate zero sacharide ODTs and investigates the effect of freezing protocol on sublimation rate and tablets characteristics. The results showed that inclusion of proline and serine improved ODT properties when compared to individual counterparts. Additionally, annealing the ODTs facilitated the sublimation process and shortened the disintegration time.