Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts
Marzouk, Mohamed S. and Moharram, Fatma A. and El Dib, Rabab A. and El-Shenawy, Siham M. and Tawfike, Ahmed F. (2009) Polyphenolic profile and bioactivity study of oenothera speciosa nutt. aerial parts. Molecules, 14 (4). pp. 1456-1467. ISSN 1420-3049 (https://doi.org/10.3390/molecules14041456)
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Abstract
Two new flavonol glycosides, myricetin 4'-O-α-L-rhamnopyranoside (1) and quercetin 3'-O-α-L-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-α-L-1C4-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-β-galacto-pyranoside (8), caffeic acid (9), caffeic acid methyl ester (10), chlorogenic acid (11), chlorogenic acid methyl ester (12), gallic acid (13) and gallic acid methyl ester (14), were identified from the 80 % methanol extract of the aerial parts (leaves and stems) of Oenothera speciosa Nutt. (Onagraceae). In addition myricetin (15), quercetin (16) and ellagic acid (17) were identified from the chloroform extract. The structures were established depending on their chemical and physical analyses (UV, HR-ESIMS, 1D and 2D NMR). It was found that 80 % aqueous methanol extract of O. speciosa is non-toxic to mice up to 5 g kg-1b.wt. The investigated extract exhibited significant antihyperglycaemic and anti-inflammatory activities in a dose dependant manner. Also, the 80 % methanol extract, myricitrin(4) and hyperin(7) showed potent antioxidant activity in vitro using 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical assay.
ORCID iDs
Marzouk, Mohamed S., Moharram, Fatma A., El Dib, Rabab A., El-Shenawy, Siham M. and Tawfike, Ahmed F. ORCID: https://orcid.org/0000-0003-2061-3093;-
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Item type: Article ID code: 57002 Dates: DateEvent7 April 2009Published26 March 2009AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 20 Jul 2016 13:51 Last modified: 05 Oct 2024 00:24 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/57002