The discovery and development of Eg5 inhibitors for the clinic
Good, James A. D. and Berretta, Giacomo and Anthony, Nahoum G. and Mackay, Simon P.; Kozielski, Frank, ed. (2015) The discovery and development of Eg5 inhibitors for the clinic. In: Kinesins and Cancer. Sense Publishers, pp. 27-52. ISBN 978-94-017-9731-3
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The mitotic kinesin Eg5 (also known as kinesin spindle protein, KSP, Kif11, a member of the kinesin-5 family) represents an attractive oncology drug target in the ongoing development of anti-mitotic drugs that selectively block mitosis through disruption to the mitotic spindle. In this state-of-the-art review, we outline the progress that has been made in the development of Eg5 inhibitors for clinical use. We evaluate the preclinical development and attributes of key Eg5 inhibitors that have undergone clinical evaluation or extensive preclinical optimisation, and discuss the medicinal chemistry strategies utilised in their design to overcome the challenges encountered during lead optimisation. We critically analyse the progress that has been made towards delivering clinical benefits, and the wider implications this has in the utility of mitotic kinesin inhibitors as prospective oncology drugs.
| Creators(s): |
Good, James A. D., Berretta, Giacomo  ORCID: https://orcid.org/0000-0002-8646-9904, Anthony, Nahoum G. ORCID: https://orcid.org/0000-0002-2026-8763 and Mackay, Simon P. ORCID: https://orcid.org/0000-0001-8000-6557;
Kozielski, Frank
| Item type: | Book Section |
|---|---|
| ID code: | 54932 |
| Keywords: | anti-mitotic, drug discovery, Eg5, kinesins, multiple myeloma, Neoplasms. Tumors. Oncology (including Cancer), Pharmacy and materia medica, Medicine(all), Biochemistry, Genetics and Molecular Biology(all), Chemistry(all), Pharmacology, Toxicology and Pharmaceutics(all) |
| Subjects: | Medicine > Internal medicine > Neoplasms. Tumors. Oncology (including Cancer) Medicine > Pharmacy and materia medica |
| Department: | University of Strathclyde > University of Strathclyde Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Pure Administrator |
| Date deposited: | 11 Dec 2015 04:25 |
| Last modified: | 05 Sep 2020 05:09 |
| Related URLs: | |
| URI: | https://strathprints.strath.ac.uk/id/eprint/54932 |
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