Quantum cascade laser-based mid-infrared spectrochemical imaging of tissue and biofluids

Tools

Clemens, Graeme and Bird, Benjamin and Weida, Miles and Rowlette, Jeremy and Baker, Matthew J. (2014) Quantum cascade laser-based mid-infrared spectrochemical imaging of tissue and biofluids. Spectroscopy Europe, 26 (4). pp. 14-19. ISSN 1522-2349 (http://www.spectroscopyeurope.com/articles/55-arti...)

[thumbnail of Clemens-etal-SE2014-quantum-cascade-laser-based-mid-infrared-spectrochemical-imaging]
Preview
 Text. Filename: Clemens_etal_SE2014_quantum_cascade_laser_based_mid_infrared_spectrochemical_imaging.pdf
Accepted Author Manuscript
Download (913kB)| Preview

Abstract

Mid-infrared spectroscopic imaging is a rapidly emerging technique in biomedical research and clinical diagnostics that takes advantage of the unique molecular fingerprint of cells, tissue and biofluids to provide a rich biochemical image without the need for staining. Spectroscopic analysis allows for the objective classification of biological material at a molecular level.1 This “label free” molecular imaging technique has been applied to histology, cytology, surgical pathology, microbiology and stem cell research, and can be used to detect subtle changes to the genome, proteome and metabolome.2,3,4 The new wealth of biochemical information made available by this technique has the distinct potential to improve cancer patient outcome through the identification of earlier stages of disease, drug resistance, new disease states and high-risk populations.4 However, despite the maturity of this science, instrumentation that provide increased sample throughput, improved image quality, a small footprint, low maintenance and require minimal spectral expertise are essential for clinical translation.

ORCID iDs

Clemens, Graeme, Bird, Benjamin, Weida, Miles, Rowlette, Jeremy and Baker, Matthew J. ORCID logoORCID: https://orcid.org/0000-0003-2362-8581;
  • Item type:Article
    ID code:54521
    Dates:
    Date
    Event
    6 August 2014
    Published
    4 August 2014
    Accepted
    Notes:This is the peer reviewed version of the following article: Clemens, G., Bird, B., Weida, M., Rowlette, J., & Baker, M. J. (2014). Quantum cascade laser-based mid-infrared spectrochemical imaging of tissue and biofluids. Spectroscopy Europe, 26(4), 14-19., which has been published in final form at http://www.spectroscopyeurope.com/articles/55-articles/3360-quantum-cascade-laser-based-mid-infrared-spectrochemical-imaging-of-tissues-and-biofluids. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:09 Oct 2015 10:57
    Last modified:11 Nov 2024 10:50
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/54521
CORE (COnnecting REpositories)