On-chip high-speed sorting of micron-sized particles for high-throughput analysis

Holmes, D. and Sandison, M.E. and Green, N.G. and Morgan, H. (2005) On-chip high-speed sorting of micron-sized particles for high-throughput analysis. IEE Proceedings Nanobiotechnology, 152 (4). pp. 129-135. ISSN 1478-1581

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Official URL: https://doi.org/10.1049/ip-nbt:20050008

Abstract

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by focussing particles into the central streamline of the main flow channel using dielectrophoretic focussing. At the sorting junction (T- or Y-junction) two sets of electrodes produce a small dielectrophoretic force that pushes the particle into one or other of the outlet channels, where they are carried under the pressure-driven fluid flow to the outlet. For a 40 microm wide and high channel, it is shown that 6 microm diameter particles can be deflected at a rate of 300/s. The principle of a fully automated sorting device is demonstrated by separating fluorescent from non-fluorescent latex beads.

Creators(s):	Holmes, D., Sandison, M.E. ORCID: https://orcid.org/0000-0003-1021-1461, Green, N.G. and Morgan, H.;
Item type:	Article
ID code:	54422
Keywords:	cell separation, electrophoresis, equipment design, equipment failure analysis, flow cytometry, flow injection analysis, microfluidic analytical techniques, microspheres, nanotechnology, particle size, ultrafiltration, Bioengineering, Materials Science (miscellaneous), Control and Systems Engineering, Electrical and Electronic Engineering
Subjects:	Technology > Engineering (General). Civil engineering (General) > Bioengineering
Department:	Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Engineering > Biomedical Engineering
Depositing user:	Pure Administrator
Date deposited:	01 Oct 2015 13:03
Last modified:	20 Jan 2021 23:28
URI:	https://strathprints.strath.ac.uk/id/eprint/54422
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