Picture of boy being examining by doctor at a tuberculosis sanatorium

Understanding our future through Open Access research about our past...

Strathprints makes available scholarly Open Access content by researchers in the Centre for the Social History of Health & Healthcare (CSHHH), based within the School of Humanities, and considered Scotland's leading centre for the history of health and medicine.

Research at CSHHH explores the modern world since 1800 in locations as diverse as the UK, Asia, Africa, North America, and Europe. Areas of specialism include contraception and sexuality; family health and medical services; occupational health and medicine; disability; the history of psychiatry; conflict and warfare; and, drugs, pharmaceuticals and intoxicants.

Explore the Open Access research of the Centre for the Social History of Health and Healthcare. Or explore all of Strathclyde's Open Access research...

Image: Heart of England NHS Foundation Trust. Wellcome Collection - CC-BY.

The hydrochloride and hydrobromide salt forms of (S)-amphetamine

Dennany, Lynn and Kennedy, Alan R. and Walker, Brandon (2015) The hydrochloride and hydrobromide salt forms of (S)-amphetamine. Acta Crystallographica Section C: Crystal Structure Communications, 71 (10). pp. 844-849. ISSN 0108-2701 (In Press)

[img]
Preview
Text (Dennany-etal-ACC-2015-The-hydrochloride-and-hydrobromide-salt-forms-of)
Dennany_etal_ACC_2015_The_hydrochloride_and_hydrobromide_salt_forms_of.pdf
Accepted Author Manuscript

Download (148kB) | Preview

Abstract

(S)-Amphetamine hydrochloride, C9H14ClN, has a Z′ = 6 structure with six independent cation, anion pairs. That these are indeed crystallographically independent is supported by different packing orientations of the cations and by observation of a wide range of cation conformations generated by rotation about the phenyl–CH2 bond. The supramolecular contacts about the anions also differ such that both a wide variation in the geometry of the three N–H···Cl hydrogen bonds formed by each chloride anion and differences in C–H···Cl contacts are apparent. (S)-Amphetamine hydrobromide, C9H14BrN, is broadly similar to the chloride in terms of cation conformation, the existance of three N–H···X hydrogen bond contacts per anion and the overall 2 dimensional hydrogen bonded sheet motif. However, only the chloride structure features organic bilayers and Z′ > 1.