Tailoring specialized metabolite production in streptomyces

Hiltner, Jana K and Hunter, Iain S and Hoskisson, Paul A (2015) Tailoring specialized metabolite production in streptomyces. In: Advances in Applied Microbiology. Elsevier, pp. 237-255. ISBN 978-0-12-802249-8

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Abstract

Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.