Insight into the esterase like activity demonstrated by an imidazole appended self-assembling hydrogelator
Singh, Nishant and Conte, Maria P. and Ulijn, R. V. and Miravet, Juan F. and Escuder, Beatriu (2015) Insight into the esterase like activity demonstrated by an imidazole appended self-assembling hydrogelator. Chemical Communications, 51 (67). pp. 13213-13216. ISSN 1359-7345 (https://doi.org/10.1039/c5cc04281j)
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Abstract
A low molecular weight hydrogelator with a covalently appended imidazole moiety is reported. Capable of percolating water in the pH range of 6 to 8, it proves to be an efficient catalyst upon self-assembly, showing Michaelis-Menten type kinetics. Activities at different pH values correlated with dramatic structural changes were observed. It can hydrolyse p-nitrophenyl acetate (pNPA) as well as inactivated esters, and l and d-phenylalanine methyl esters. The enhanced activity can be related to the conglomeration of catalytic groups upon aggregation resulting in their close proximity and the formation of hydrophobic pockets.
ORCID iDs
Singh, Nishant, Conte, Maria P. ORCID: https://orcid.org/0000-0001-8706-4901, Ulijn, R. V. ORCID: https://orcid.org/0000-0001-7974-3779, Miravet, Juan F. and Escuder, Beatriu;-
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Item type: Article ID code: 54158 Dates: DateEvent28 August 2015Published10 July 2015Published Online9 July 2015AcceptedSubjects: Science > Chemistry Department: University of Strathclyde > University of Strathclyde
Faculty of Science > Pure and Applied Chemistry
Technology and Innovation Centre > BionanotechnologyDepositing user: Pure Administrator Date deposited: 04 Sep 2015 10:48 Last modified: 21 Oct 2024 01:17 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/54158