The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA)
Connor, Lauren E. and Delori, Amit and Hutchison, Ian B. and Nic Daeid, Niamh and Sutcliffe, Oliver B. and Oswald, Iain D. H. (2015) The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA). Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 71 (1). pp. 3-9. ISSN 2052-5192 (https://doi.org/10.1107/S2052520614026389)
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Abstract
MDMA (3,4-methylenedioxymethamphetamine) is a Class A substance that is usually found in a tableted form. It is only observed in one orthorhombic polymorph under ambient conditions. It shows slight positional disorder around the methlyenedioxy ring which persists during compression up to 6.66 GPa. The crystal quality deteriorates above 6.66 GPa where the hydrostatic limit of the pressure-transmitting medium is exceeded. The structure undergoes anisotropic compression with the a-axis compressing the greatest (12% cf. 4 and 10% for the b- and c-axes, respectively). This is due to the pattern of the hydrogen bonding which acts like a spring and allows the compression along this direction.
ORCID iDs
Connor, Lauren E. ORCID: https://orcid.org/0000-0002-4626-8921, Delori, Amit, Hutchison, Ian B., Nic Daeid, Niamh, Sutcliffe, Oliver B. and Oswald, Iain D. H. ORCID: https://orcid.org/0000-0003-4339-9392;-
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Item type: Article ID code: 53784 Dates: DateEvent2 February 2015Published13 November 2014AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 16 Jul 2015 09:54 Last modified: 11 Nov 2024 10:56 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/53784