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Synthesis and application of an oxytetracycline imprinted polymer for the solid-phase extraction of tetracycline antibiotics

Caro, E. and Marce, R.M. and Cormack, P.A.G. and Sherrington, D.C. and Borrull, F. (2005) Synthesis and application of an oxytetracycline imprinted polymer for the solid-phase extraction of tetracycline antibiotics. Analytica Chimica Acta, 552 (1-2). pp. 81-86. ISSN 0003-2670

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Abstract

Two molecularly imprinted polymers (MIPs) were synthesised using tetracycline and oxytetracycline antibiotics as template molecules in non-covalent molecular imprinting procedures. After a chromatographic evaluation, the performance of the MIPs as selective SPE sorbents was evaluated. In this study, it was demonstrated that after a clean-up step to disrupt the non-specific interactions between the MIPs and the compounds retained on them, the polymers showed cross-reactivity for certain other tetracycline analytes. The feasibility of the MIP to selectively extract tetracycline antibiotics in pig kidney tissue extract was demonstrated with the oxytetracycline MIP which gave rise to the best MISPE results when it was applied. Good recoveries were obtained when oxytetracycline and tetracycline were selectively extracted from 25 ml of pig kidney tissue extract.

Item type: Article
ID code: 536
Keywords: column liquid chromatography, solid-phase extraction, molecularly imprinted polymer, tetracycline antibiotics, tissue samples, Chemistry, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry
Subjects: Science > Chemistry
Department: Faculty of Science > Pure and Applied Chemistry
Depositing user: Mr Derek Boyle
Date deposited: 16 Mar 2006
Last modified: 25 Jan 2019 03:03
URI: https://strathprints.strath.ac.uk/id/eprint/536
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