A microfluidics platform for human tau mutation neurons

Torrance, Emma and Robertson, Graham and Wray, Selina and Hardy, John and Bushell, Trevor and Zagnoni, Michele (2014) A microfluidics platform for human tau mutation neurons. In: MicroTAS 2014. CBM Society, San Diego, CA., pp. 898-890. ISBN 9780979806476

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Abstract

This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.