Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

Brown, Cameron J. and Ni, Xiong Wei (2012) Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer. CrystEngComm, 14 (8). pp. 2944-2949. ISSN 1466-8033

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Abstract

This work aims to show the viability of applying video imaging techniques to the cooling crystallization of paracetamol in an oscillatory baffled crystallizer for the determination of the metastable zone width and crystal size distribution. From these data, the effects of supersaturation and mixing on metastable zone width and mean particle size are examined. Both sets of data are in good agreement with previous studies in a stirred tank and oscillatory baffled crystallizers. Finally, utilizing the Kubota's interpretation of metastable zone width, we demonstrated that the video imaging techniques are as sensitive to nucleation events as FBRM probes.

Author(s):Brown, Cameron J. ORCID logoORCID: https://orcid.org/0000-0001-7091-1721 and Ni, Xiong Wei
Item type:Article
ID code:53334
Keywords:cooling crystallization, paracetamol, oscillatory baffled crystallizer, crystal size distribution, Pharmacy and materia medica, Chemistry, Chemistry(all), Materials Science(all), Condensed Matter Physics
Subjects:Medicine > Pharmacy and materia medica
Science > Chemistry
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:10 Jun 2015 11:30
Last modified:30 Aug 2019 03:28
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URI:https://strathprints.strath.ac.uk/id/eprint/53334
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