Evaluation of growth kinetics of antisolvent crystallization of paracetamol in an oscillatory baffled crystallizer utilizing video imaging
Brown, Cameron J. and Ni, Xiong Wei (2011) Evaluation of growth kinetics of antisolvent crystallization of paracetamol in an oscillatory baffled crystallizer utilizing video imaging. Crystal Growth and Design, 11 (9). pp. 3994-4000. ISSN 1528-7483 (https://doi.org/10.1021/cg200560b)
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This work aims to show the potential of applying video imaging techniques to antisolvent crystallization of paracetamol in an oscillatory baffled crystallizer for the determination of crystal size distribution and mean crystal size with a high level of accuracy in comparison with the values measured with a Mastersizer. From these data, the effects of supersaturation, addition rate, and mixing on growth rate are examined and crystal growth kinetics extracted for various operational parameters. The kinetic data so generated are in good agreement with these from previous studies in stirred tank systems. It was found that the degree of supersaturation has the most significant effect on the overall growth rates, followed closely by the degree of mixing and then the rate of antisolvent addition. Both the kinetics and process data could be used as the tool for the design and operation of antisolvent crystallization.
ORCID iDs
Brown, Cameron J. ORCID: https://orcid.org/0000-0001-7091-1721 and Ni, Xiong Wei;-
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Item type: Article ID code: 53333 Dates: DateEvent7 September 2011Published11 July 2011Published OnlineSubjects: Medicine > Pharmacy and materia medica
Science > ChemistryDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 10 Jun 2015 11:25 Last modified: 11 Nov 2024 11:06 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/53333