Online evaluation of paracetamol antisolvent crystallization growth rate with video imaging in an oscillatory baffled crystallizer
Brown, Cameron J. and Ni, Xiongwei (2011) Online evaluation of paracetamol antisolvent crystallization growth rate with video imaging in an oscillatory baffled crystallizer. Crystal Growth and Design, 11 (3). pp. 719-725. ISSN 1528-7483 (https://doi.org/10.1021/cg1011988)
Full text not available in this repository.Request a copyAbstract
We report a method for observing and quantifying antisolvent crystallization (acetone/water system) of paracetamol in an oscillatory baffled crystallizer (OBC). With the help of optical means, paracetamol crystals passing the light sheet are recorded by a CCD camera. This allows the mass of crystals to be tracked with time and in turn the instantaneous and overall averaged crystal mass growth rates to be evaluated. By the standard sampling method, the overall averaged crystal growth rate and the percentage recovery of crystals were also determined. This work shows that there is a high correlation in data between the optical and the sampling techniques, validating the accuracy and reliability of the system. Our data are also consistent with previous work in this field.
ORCID iDs
Brown, Cameron J. ORCID: https://orcid.org/0000-0001-7091-1721 and Ni, Xiongwei;-
-
Item type: Article ID code: 53332 Dates: DateEvent2 March 2011PublishedSubjects: Medicine > Pharmacy and materia medica
Science > ChemistryDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 10 Jun 2015 11:13 Last modified: 11 Nov 2024 11:06 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/53332