Photoluminescent nanosensors for intracellular detection

De La Rica, Roberto and Kerr, Caitlin (2015) Photoluminescent nanosensors for intracellular detection. Analytical Methods. ISSN 1759-9660 (https://doi.org/10.1039/C5AY00489F)

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Abstract

In this manuscript we review the main strategies for detecting changes in intracellular parameters with photoluminescent nanosensors. Examples of the detection of intracellular pH, ion concentration (Na+, Ca2+, Zn2+, Hg2+), reactive oxygen species (ROS, e.g. hydrogen peroxide), variations in temperature, changes in RNA levels and the detection of enzymatic activity are described in detail. The utilisation of nanomaterials such as quantum dots, silicon carbide nanoparticles, nanoscale metal-organic frameworks, upconverting nanoparticles, fluorescent nanoclusters, gold nanoparticles, nanodiamonds, dendrimers and polymeric nanoparticles in bioimaging is highlighted. When compared to molecular probes, nanosensors combine high sensitivity and selectivity with low toxicity, which are crucial parameters for sensing in live cells.

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  Item type:	Article
  ID code:	52495
  Dates:	Date Event 2015 Published 2 April 2015 Published Online 1 April 2015 Accepted
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	09 Apr 2015 11:46
  Last modified:	11 Nov 2024 11:02
  URI:	https://strathprints.strath.ac.uk/id/eprint/52495