Photoluminescent nanosensors for intracellular detection

De La Rica, Roberto and Kerr, Caitlin (2015) Photoluminescent nanosensors for intracellular detection. Analytical Methods. ISSN 1759-9660 (https://doi.org/10.1039/C5AY00489F)

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Abstract

In this manuscript we review the main strategies for detecting changes in intracellular parameters with photoluminescent nanosensors. Examples of the detection of intracellular pH, ion concentration (Na+, Ca2+, Zn2+, Hg2+), reactive oxygen species (ROS, e.g. hydrogen peroxide), variations in temperature, changes in RNA levels and the detection of enzymatic activity are described in detail. The utilisation of nanomaterials such as quantum dots, silicon carbide nanoparticles, nanoscale metal-organic frameworks, upconverting nanoparticles, fluorescent nanoclusters, gold nanoparticles, nanodiamonds, dendrimers and polymeric nanoparticles in bioimaging is highlighted. When compared to molecular probes, nanosensors combine high sensitivity and selectivity with low toxicity, which are crucial parameters for sensing in live cells.

  • Item type:Article
    ID code:52495
    Dates:
    Date
    Event
    2015
    Published
    2 April 2015
    Published Online
    1 April 2015
    Accepted
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:09 Apr 2015 11:46
    Last modified:11 Nov 2024 11:02
    URI:https://strathprints.strath.ac.uk/id/eprint/52495
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