Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes

Porteous, D.J. and Evans, K.L. and Millar, J.K. and Pickard, B.S. and Thomson, P.A. and James, R. and MacGregor, S. and Wray, N.R. and Visscher, P.M. and Muir, W.J. and Blackwood, D.H. (2003) Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes. Cold Spring Harbor symposia on quantitative biology, 68. pp. 383-394. ISSN 1943-4456

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Abstract

Schizophrenia (SCZ) and bipolar affective disorder(BPAD) (formerly termed manic-depressive illness) aresevere, disabling psychiatric illnesses that feature prominently in the top ten causes of disability worldwide (Lopezand Murray 1998). Each will affect about 1% of the population in their lifetime.