Novel treatment strategies for schizophrenia from improved understanding of genetic risk
Morris, B.J. and Pratt, J.A. (2014) Novel treatment strategies for schizophrenia from improved understanding of genetic risk. Clinical Genetics, 86 (5). pp. 401-411. ISSN 0009-9163 (https://doi.org/10.1111/cge.12485)
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Abstract
Recent years have seen significant advances in our understanding of the genetic basis of schizophrenia. In particular, genome-wide approaches have suggested the involvement of many common genetic variants of small effect, together with a few rare variants exerting relatively large effects. While unequivocal identification of the relevant genes has, for the most part, remained elusive, the genes revealed as potential candidates can in many cases be clustered into functionally-related groups which are potentially open to therapeutic intervention. In this review, we summarise this information, focussing on the accumulating evidence that genetic dysfunction at glutamatergic synapses and post-synaptic signalling complexes contributes to the aetiology of the disease. In particular, there is converging support for involvement of post-synaptic JNK pathways in disease aetiology. An expansion of our neurobiological knowledge of the basis of schizophrenia is urgently needed, yet some promising novel pharmacological targets can already be discerned.
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Item type: Article ID code: 52110 Dates: DateEventNovember 2014Published16 September 2014Published Online15 August 2014AcceptedNotes: This is the accepted version of the following article: Morris, B.J. and Pratt, J.A. (2014), Novel treatment strategies for schizophrenia from improved understanding of genetic risk. Clinical Genetics, 86: 401–411, which has been published in final form at http://doi.org/10.1111/cge.12485. Subjects: Medicine > Therapeutics. Pharmacology
Science > Natural history > GeneticsDepartment: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 05 Mar 2015 14:30 Last modified: 16 Oct 2024 00:24 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/52110