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Strathprints makes available scholarly Open Access content by the Fraser of Allander Institute (FAI), a leading independent economic research unit focused on the Scottish economy and based within the Department of Economics. The FAI focuses on research exploring economics and its role within sustainable growth policy, fiscal analysis, energy and climate change, labour market trends, inclusive growth and wellbeing.

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The NPAS3 gene--emerging evidence for a role in psychiatric illness

Pickard, Benjamin S. and Pieper, Andrew A. and Porteous, David J. and Blackwood, Douglas H. and Muir, Walter J. (2006) The NPAS3 gene--emerging evidence for a role in psychiatric illness. Annals of medicine, 38 (6). pp. 439-448. ISSN 1365-2060

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Abstract

NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.