Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy : measurements of acetaminophen solubility in a wide range of state parameters
Oparin, Roman D. and Idrissi, Abdenacer and Fedorov, Maxim V. and Kiselev, Michael G. (2014) Dynamic and static characteristics of drug dissolution in supercritical CO2 by infrared spectroscopy : measurements of acetaminophen solubility in a wide range of state parameters. Journal of Chemical and Engineering Data, 59 (11). pp. 3517-3523. ISSN 0021-9568 (https://doi.org/10.1021/je500456s)
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Abstract
In this work we use infrared spectroscopy to investigate solubility properties of a bioactive substance in supercritical CO2 (scCO2). By using acetaminophen as a model compound, we show that the method can provide high sensitivity that makes it possible to study solubility at small concentrations, up to 10-6 mol·L-1. This method also allows one to investigate the kinetics of the dissolution process in supercritical solvent. Our measurements at two different points of the (p, T) plane ((40 MPa, 373 K) and (40 MPa, 473 K)) have shown significant difference in the kinetic mechanisms of acetaminophen dissolution at these two states: at higher temperature the dissolution process in scCO2 has two steps: (i) "fast" step when the acetaminophen concentration in scCO2 quickly reaches (70 to 80) % of the saturation level and (ii) a subsequent "slow" step where the acetaminophen concentration slowly increases up to the saturation level. However, at lower temperature, the dissolution process has only one, "slow" step.
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Item type: Article ID code: 51627 Dates: DateEvent13 November 2014Published23 September 2014Published Online3 September 2014AcceptedSubjects: Technology > Chemical engineering Department: Faculty of Science > Physics
Technology and Innovation Centre > Bionanotechnology
University of Strathclyde > University of StrathclydeDepositing user: Pure Administrator Date deposited: 12 Feb 2015 15:32 Last modified: 11 Aug 2024 12:45 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/51627