Computational modelling of the hybrid procedure in hypoplastic left heart syndrome : a comparison of zero-dimensional and three-dimensional approach.
Young, Andrew and Gourlay, Terry and McKee, Sean and Danton, Mark H.D. (2014) Computational modelling of the hybrid procedure in hypoplastic left heart syndrome : a comparison of zero-dimensional and three-dimensional approach. Medical Engineering and Physics, 36 (11). pp. 1549-1553. ISSN 1350-4533
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Abstract
Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits clinical application. Simpler, zero-dimensional models utilize external PAB diameters [dext] and provide rapid analysis, which may better guide intervention. This study compared 0-D and 3-D modelling from a single patient dataset and investigated the relationship dint versus dext and hemodynamic outputs of the two models. Optimum oxygen delivery defined at dint = 2 mm corresponded to dext = 3.1 mm and 3.4 mm when models were matched for cardiac output or systemic pressure, respectively. 0-D and 3-D models when matched for PAB dimension produced close equivalence of hemodynamics and ventricular energetics. From this study we conclude that 0-D model can provide a valid alternative to 3D-multiscale in the hybrid–HLHS circulation.
Creators(s): | Young, Andrew, Gourlay, Terry, McKee, Sean and Danton, Mark H.D.; | Item type: | Article |
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ID code: | 51081 |
Keywords: | Paediatric surgery, hypoplastic left heart, modelling, Bioengineering, Medicine(all), Mathematics(all) |
Subjects: | Technology > Engineering (General). Civil engineering (General) > Bioengineering |
Department: | Faculty of Engineering > Biomedical Engineering Faculty of Science > Mathematics and Statistics |
Depositing user: | Pure Administrator |
Date deposited: | 14 Jan 2015 16:24 |
Last modified: | 20 Jan 2021 21:43 |
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URI: | https://strathprints.strath.ac.uk/id/eprint/51081 |
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