Immunostimulatory lipid nanoparticles from herbal medicine

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Hasson, Tal H. and Takaoka, Anna and De La Rica, Roberto and Matsui, Hiroshi and Smeureanu, Gabriela and Drain, Charles Michael and Kawamura, Akira (2014) Immunostimulatory lipid nanoparticles from herbal medicine. Chemical Biology and Drug Design, 83 (4). 493–497. ISSN 1747-0285 (https://doi.org/10.1111/cbdd.12250)

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Abstract

Reproducibility is an important issue in biological characterization of drug candidates and natural products. It is not uncommon to encounter cases in which supposedly the same sample exhibits very different biological activities. During our characterization of macrophage-stimulatory lipids from herbal medicine, it was found that the potency of these lipids could vary substantially from experiment to experiment. Further analysis of this reproducibility issue led to the discovery of solvent-dependent nanoparticle formation by these lipids. While larger nanoparticles (approximately 100 nm) of these lipids showed modest macrophage-stimulatory activity, smaller nanoparticles (<10 nm) of the same lipids exhibited substantially higher potency. Thus, the study revealed an unexpected link between nanoparticle formation and macrophage-stimulatory activity of plant lipids. Although nanoparticles have been extensively studied in the context of vehicles for drug delivery, our finding indicates that drugs themselves can form nanoassemblies, and their biological properties may be altered by the way they assemble.

  • Item type:Article
    ID code:50795
    Dates:
    Date
    Event
    April 2014
    Published
    5 February 2014
    Published Online
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:12 Dec 2014 15:12
    Last modified:11 Nov 2024 10:53
    URI:https://strathprints.strath.ac.uk/id/eprint/50795
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