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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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A unified mixed-integer programming model for simultaneous fluence weight and aperture optimization in VMAT, Tomotherapy, and Cyberknife

Akartunali, Kerem and Mak-Hau, Vicky and Tran, Thu (2015) A unified mixed-integer programming model for simultaneous fluence weight and aperture optimization in VMAT, Tomotherapy, and Cyberknife. Computers & Operations Research, 56. pp. 134-150. ISSN 0305-0548

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In this paper, we propose and study a unified mixed-integer programming model that simultaneously optimizes fluence weights and multi-leaf collimator (MLC) apertures in the treatment planning optimization of VMAT, Tomotherapy, and CyberKnife. The contribution of our model is threefold: i. Our model optimizes the fluence and MLC apertures simultaneously for a given set of control points. ii. Our model can incorporate all volume limits or dose upper bounds for organs at risk (OAR) and dose lower bound limits for planning target volumes (PTV) as hard constraints, but it can also relax either of these constraint sets in a Lagrangian fashion and keep the other set as hard constraints. iii. For faster solutions, we propose several heuristic methods based on the MIP model, as well as a meta-heuristic approach. The meta-heuristic is very efficient in practice, being able to generate dose- and machinery-feasible solutions for problem instances of clinical scale, e.g., obtaining feasible treatment plans to cases with 180 control points, 6,750 sample voxels and 18,000 beamlets in 470 seconds, or cases with 72 control points, 8,000 sample voxels and 28,800 beamlets in 352 seconds. With discretization and down-sampling of voxels, our method is capable of tackling a treatment field of 8000cm3∼64000cm3, depending on the ratio of critical structure versus unspecified tissues.