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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

Explore research outputs by the European Policies Research Centre...

Determination of an optimal axial-length tension for the study of isolated resistance arteries on a pressure myograph

Coats, P and Hillier, C (1999) Determination of an optimal axial-length tension for the study of isolated resistance arteries on a pressure myograph. Experimental Physiology, 84 (6). 1085–1094. ISSN 0958-0670

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Abstract

The effects of longitudinal stretch on vasoreactivity were assessed in isolated, pressurised arteries from the rat mesentery, rat mid-cerebral and human subcutaneous vascular beds. A stretch-dependent increase in reactivity was observed only in rat third order mesenteric arteries. Longitudinal stretch > 20 % (force equal to 0.23 +/- 0.04 mN) optimises vasoconstrictor responses to noradrenaline and phenylephrine in rat third order mesenteric arteries. Stretch did not affect the vasoconstriction response to depolarisation by 30 mM K+ PSS in any of the arteries studied. Similarly, stretch had no affect on pressure-dependent myogenic responses in rat mid-cerebral arteries. Endothelium-independent and endothelium-dependent mechanisms of vasorelaxation were unaffected by stretch in rat third order mesenteric arteries. Likewise, stretch did not affect vasoreactivity in rat mid-cerebral and human subcutaneous resistance arteries. Our results show that longitudinal stretch in isobaric-mounted rat third order mesenteric arteries is an important methodological consideration. Considering our results, we recommend that isobaric-mounted rat third order mesenteric arteries are stretched > 20 % to provide optimal experimental conditions for pharmacological studies.