Usefulness of intermuscular coherence and cumulant analysis in the diagnosis of postural tremor

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van der Stouwe, A.M.M. and Conway, Bernard A and Elting, J.W. and Tijssen, M.A.J. and Maurits, Natasha M. (2014) Usefulness of intermuscular coherence and cumulant analysis in the diagnosis of postural tremor. Clinical Neurophysiology. ISSN 1388-2457 (https://doi.org/10.1016/j.clinph.2014.10.157)

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Abstract

This article investigate the potential value of two advanced EMG measures as additional diagnostic measures in the polymyographic assessment of postural upper-limb tremor.  We investigated coherence as a measure of dependency between two EMG signals, and cumulant analysis to reveal patterns of synchronicity in EMG activity in muscle pairs. Eighty datasets were analyzed retrospectively, obtained from four groups: essential tremor (ET), Parkinson’s disease (PD), enhanced physiological tremor (EPT), and functional tremor (FT).  Intermuscular coherence was highest in the PD group (0.58), intermediate in FT (0.43) and ET (0.40), and weakest in EPT (0.16) (p=0.002). EPT patients could be distinguished by low coherence: coherence<0.18 in the wrist + elbow extensors differentiates EPT in this sample with a sensitivity of 86% and specificity of 84%.  Cumulant analysis showed predominantly alternating activity between wrist and elbow extensor in ET patients, while a more synchronous pattern was predominant in PD, EPT and FT (p=0.008). EMG activity in wrist and elbow flexors tended to be more synchronous in PD (p=0.059).Our results suggest that coherence and cumulant analysis may be of additional value in the diagnostic work-up of postural tremor.  These additional measures may be helpful in diagnosing difficult tremor cases.

ORCID iDs

van der Stouwe, A.M.M., Conway, Bernard A ORCID logoORCID: https://orcid.org/0000-0002-0069-0131, Elting, J.W., Tijssen, M.A.J. and Maurits, Natasha M.;
  • Item type:Article
    ID code:50348
    Dates:
    Date
    Event
    2014
    Published
    8 November 2014
    Published Online
    28 October 2014
    Accepted
    Notes:“NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Neurophysiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Neurophysiology, [VOL#, ISSUE#, (08/11/14)] DOI:10.1016/j.clinph.2014.10.157
    Subjects:Technology > Engineering (General). Civil engineering (General) > Bioengineering
    Department:Faculty of Engineering > Biomedical Engineering
    Depositing user: Pure Administrator
    Date deposited:14 Nov 2014 10:49
    Last modified:02 Dec 2024 01:15
    URI:https://strathprints.strath.ac.uk/id/eprint/50348
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