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Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

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Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry

Baker, Matthew J. and Brown, Michael D. and Gazi, Ehsan and Clarke, Noel W. and Vickerman, John C. and Lockyer, Nicholas P. (2008) Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry. Analyst, 133 (2). pp. 175-179. ISSN 0003-2654

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Abstract

This communication utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with multivariate analysis to obtain spectra from the surfaces of three closely related cell lines allowing their discrimination based upon mass spectral ions.