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Investigating FTIR based histopathology for the diagnosis of prostate cancer

Baker, Matthew J. and Gazi, Ehsan and Brown, Michael D. and Shanks, Jonathan H. and Clarke, Noel W. and Gardner, Peter (2009) Investigating FTIR based histopathology for the diagnosis of prostate cancer. Journal of Biophotonics, 2 (1-2). pp. 104-113. ISSN 1864-063X

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Abstract

Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, is subjective and limited by variation between different pathologists. The diagnostic problems associated with the correct grading and staging of prostate cancer (CaP) has led to an interest in the development of spectroscopic based diagnostic techniques. FTIR microspectroscopy used in combination with a Principal Component Discriminant Function Analysis (PC-DFA) was applied to investigate FTIR based histopathology for the diagnosis of CaP. In this paper we report the results of a large patient study in which FTIR has been proven to grade CaP tissue specimens to a high degree of sensitivity and specificity.