Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae)

Bafor, Enitome and Lim, C. V. and Rowan, Edward and Edrada-Ebel, Ruangelie (2012) Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae). In: American Society of Pharmacognosy Meeting : 2012 Annual Meeting, 2012-07-28 - 2012-07-31.

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Abstract

New potential lead uterine active agents for the safe and effective management and/or therapy of dysfunctional uterine activities were isolated from the leaves of the tropical plant F. exasperata via in vitro bioassay-guided functional uterine assays as well as several spectroscopic procedures which included 1D, 2D NMR and LC-HRMS. A total of 17 active compounds comprising four fatty acids, one triglyceride, six pheophorbide related compounds, four flavonoids, one pyrimidine, and an inorganic salt were identified from the ethylacetate and methanol extracts. Metabolomic tools were used to further investigate pathways that were down and/or up regulated during uterine activities.

  • Item type:Conference or Workshop Item(Poster)
    ID code:49689
    Dates:
    Date
    Event
    July 2012
    Published
    Notes:Recipient of "Best poster award". Published as a "Congress abstract" in Planta Medica, Vol.78 No.11, 2012.
    Keywords:dysfunctional uterine activities, F. exasperata, ethylacetate extracts, methanol extracts, pharmacology, toxicology and pharmaceutics, applied microbiology and biotechnology, Therapeutics. Pharmacology, Botany, Pharmacology, Toxicology and Pharmaceutics(all), Applied Microbiology and Biotechnology
    Subjects:Medicine > Therapeutics. Pharmacology
    Science > Botany
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:08 Oct 2014 09:28
    Last modified:18 Mar 2021 01:54
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/49689
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