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Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae)

Bafor, Enitome and Lim, C. V. and Rowan, Edward and Edrada-Ebel, Ruangelie (2012) Systematic isolation and metabolomic analysis of uterine active compounds from the leaf extracts of Ficus exasperata (Moraceae). In: American Society of Pharmacognosy Meeting : 2012 Annual Meeting, 2012-07-28 - 2012-07-31.

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Abstract

New potential lead uterine active agents for the safe and effective management and/or therapy of dysfunctional uterine activities were isolated from the leaves of the tropical plant F. exasperata via in vitro bioassay-guided functional uterine assays as well as several spectroscopic procedures which included 1D, 2D NMR and LC-HRMS. A total of 17 active compounds comprising four fatty acids, one triglyceride, six pheophorbide related compounds, four flavonoids, one pyrimidine, and an inorganic salt were identified from the ethylacetate and methanol extracts. Metabolomic tools were used to further investigate pathways that were down and/or up regulated during uterine activities.