The role of phosphatidylinositol 4,5 bisphosphate breakdown in cell-surface receptor activation

Kirk, C J and Bone, E A and Palmer, S and Michell, R H (1984) The role of phosphatidylinositol 4,5 bisphosphate breakdown in cell-surface receptor activation. Journal of Receptor Research, 4 (1-6). pp. 489-504. ISSN 1532-4281

Abstract

The activation of Ca2+-mobilising receptors on hepatocytes and many other cells leads to a prompt reduction in the cellular content of inositol phospholipids. The primary event which underlies these changes is, most probably, a phospholipase C-catalysed attack upon phosphatidylinositol 4,5 bisphosphate. The receptor-mediated breakdown of this lipid in stimulated cells is: (i) not mediated by an increase in cytosol [Ca2+] and (ii) closely coupled to receptor occupation. Phosphatidylinositol 4,5 bisphosphate degradation may be studied by measuring the appearance of the water-soluble product, inositol trisphosphate (and its metabolites: inositol bisphosphate and inositol monophosphate), in stimulated cells. Recent evidence indicates that inositol trisphosphate and the lipid soluble product of phosphatidylinositol 4,5 bisphosphate breakdown, 1,2 diacylglycerol, may act as 'second messengers' which mediate the effects of many extracellular signals in stimulated cells.

ORCID iDs

Palmer, S ORCID: https://orcid.org/0000-0002-6608-9584

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• Item metadata

  Item type:	Article
  ID code:	49661
  Dates:	Date Event 1984 Published
  Subjects:	Medicine > Therapeutics. Pharmacology
  Department:	UNSPECIFIED
  Depositing user:	Pure Administrator
  Date deposited:	07 Oct 2014 13:32
  Last modified:	11 Nov 2024 10:46
  URI:	https://strathprints.strath.ac.uk/id/eprint/49661