Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia
Edrada, Ru Angelie and Proksch, Peter and Wray, Victor and Christ, Ruprecht and Witte, Ludger and Van Soest, Rob W M (1996) Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia. Journal of Natural Products, 59 (10). pp. 973-976. ISSN 0163-3864
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An undescribed Philippine marine sponge of the genus Xestospongia afforded four isoquinoline quinones: the new N-ethylene methyl ketone derivative of renierone (1), as well as the known compounds 1,6-dimethyl-7- methoxy-5,8-dihydroisoquinoline-5,8-dione (2), renierone (3), and mimosamycin (4). Compound 2 exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis (EC 50 of 35 ppm and LC 50 of 521 ppm) when incorporated into artificial diet. Compounds 1 and 3 were only weakly active toward S. littoralis, while compound 4 was found to be inactive. All four isolated compounds were active against the Gram-positive bacteria Bacillus subtilis and Staphyloccoccus aureus. Compound 4 was also active against the fungus Cladosporium cucumerinum.
Creators(s): | Edrada, Ru Angelie, Proksch, Peter, Wray, Victor, Christ, Ruprecht, Witte, Ludger and Van Soest, Rob W M; | Item type: | Article |
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ID code: | 49651 |
Keywords: | Philippine marine sponges, Xestospongia, isoquinoline quinones, Pharmacy and materia medica, Natural history, Plant Science, Chemistry (miscellaneous), Organic Chemistry, Drug Discovery, Pharmacology |
Subjects: | Medicine > Pharmacy and materia medica Science > Natural history |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
Depositing user: | Pure Administrator |
Date deposited: | 07 Oct 2014 09:57 |
Last modified: | 12 Nov 2020 10:10 |
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URI: | https://strathprints.strath.ac.uk/id/eprint/49651 |
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