Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia

Edrada, Ru Angelie and Proksch, Peter and Wray, Victor and Christ, Ruprecht and Witte, Ludger and Van Soest, Rob W M (1996) Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia. Journal of Natural Products, 59 (10). pp. 973-976. ISSN 0163-3864

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Abstract

An undescribed Philippine marine sponge of the genus Xestospongia afforded four isoquinoline quinones: the new N-ethylene methyl ketone derivative of renierone (1), as well as the known compounds 1,6-dimethyl-7- methoxy-5,8-dihydroisoquinoline-5,8-dione (2), renierone (3), and mimosamycin (4). Compound 2 exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis (EC 50 of 35 ppm and LC 50 of 521 ppm) when incorporated into artificial diet. Compounds 1 and 3 were only weakly active toward S. littoralis, while compound 4 was found to be inactive. All four isolated compounds were active against the Gram-positive bacteria Bacillus subtilis and Staphyloccoccus aureus. Compound 4 was also active against the fungus Cladosporium cucumerinum.

Author(s):Edrada, Ru Angelie, Proksch, Peter, Wray, Victor, Christ, Ruprecht, Witte, Ludger and Van Soest, Rob W M
Item type:Article
ID code:49651
Keywords:Philippine marine sponges, Xestospongia, isoquinoline quinones, Pharmacy and materia medica, Natural history, Plant Science, Chemistry (miscellaneous), Organic Chemistry, Drug Discovery, Pharmacology
Subjects:Medicine > Pharmacy and materia medica
Science > Natural history
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:07 Oct 2014 09:57
Last modified:31 May 2019 02:39
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URI:https://strathprints.strath.ac.uk/id/eprint/49651
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