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Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia

Edrada, Ru Angelie and Proksch, Peter and Wray, Victor and Christ, Ruprecht and Witte, Ludger and Van Soest, Rob W M (1996) Bioactive isoquinoline quinone from an undescribed Philippine marine sponge of the genus Xestospongia. Journal of Natural Products, 59 (10). pp. 973-976. ISSN 0163-3864

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An undescribed Philippine marine sponge of the genus Xestospongia afforded four isoquinoline quinones: the new N-ethylene methyl ketone derivative of renierone (1), as well as the known compounds 1,6-dimethyl-7- methoxy-5,8-dihydroisoquinoline-5,8-dione (2), renierone (3), and mimosamycin (4). Compound 2 exhibited insecticidal activity toward neonate larvae of the polyphagous pest insect Spodoptera littoralis (EC 50 of 35 ppm and LC 50 of 521 ppm) when incorporated into artificial diet. Compounds 1 and 3 were only weakly active toward S. littoralis, while compound 4 was found to be inactive. All four isolated compounds were active against the Gram-positive bacteria Bacillus subtilis and Staphyloccoccus aureus. Compound 4 was also active against the fungus Cladosporium cucumerinum.