Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

Christoforou, A and McGhee, K A and Morris, S W and Thomson, P A and McLean, A and Torrance, H S and Le Hellard, S and Pickard, B S and StClair, D and Muir, W J and Blackwood, D H and Porteous, D J and Evans, K L (2011) Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p. Molecular Psychiatry, 16 (3). pp. 240-242. ISSN 1359-4184

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Abstract

Several strong candidate genes and regions have been implicated in bipolar disorder (BP) and schizophrenia (SCZ) through linkage and association studies. These disorders have also recently been studied in genome-wide association studies (GWAS), identifying further putative candidate loci, albeit with lower levels of significance and reproducibility than in GWAS of other complex disorders.