Early signalling events of autophagy
Gallagher, Laura E and Chan, Edmond Y W (2013) Early signalling events of autophagy. Essays in Biochemistry, 55. pp. 1-15. ISSN 1744-1358
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Autophagy is a conserved cellular degradative process important for cellular homoeostasis and survival. An early committal step during the initiation of autophagy requires the actions of a protein kinase called ATG1 (autophagy gene 1). In mammalian cells, ATG1 is represented by ULK1 (uncoordinated-51-like kinase 1), which relies on its essential regulatory cofactors mATG13, FIP200 (focal adhesion kinase family-interacting protein 200 kDa) and ATG101. Much evidence indicates that mTORC1 [mechanistic (also known as mammalian) target of rapamycin complex 1] signals downstream to the ULK1 complex to negatively regulate autophagy. In this chapter, we discuss our understanding on how the mTORC1-ULK1 signalling axis drives the initial steps of autophagy induction. We conclude with a summary of our growing appreciation of the additional cellular pathways that interconnect with the core mTORC1-ULK1 signalling module.
| Creators(s): |
Gallagher, Laura E  ORCID: https://orcid.org/0000-0003-0423-1909 and Chan, Edmond Y W;
| Item type: | Article |
|---|---|
| ID code: | 49427 |
| Keywords: | animals, autophagy, homeostasis, humans, signal transduction, Pharmacy and materia medica, Biochemistry |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Pure Administrator |
| Date deposited: | 30 Sep 2014 14:22 |
| Last modified: | 08 Sep 2020 03:12 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/49427 |
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