Early signalling events of autophagy

Gallagher, Laura E and Chan, Edmond Y W (2013) Early signalling events of autophagy. Essays in Biochemistry, 55. pp. 1-15. ISSN 1744-1358

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Abstract

Autophagy is a conserved cellular degradative process important for cellular homoeostasis and survival. An early committal step during the initiation of autophagy requires the actions of a protein kinase called ATG1 (autophagy gene 1). In mammalian cells, ATG1 is represented by ULK1 (uncoordinated-51-like kinase 1), which relies on its essential regulatory cofactors mATG13, FIP200 (focal adhesion kinase family-interacting protein 200 kDa) and ATG101. Much evidence indicates that mTORC1 [mechanistic (also known as mammalian) target of rapamycin complex 1] signals downstream to the ULK1 complex to negatively regulate autophagy. In this chapter, we discuss our understanding on how the mTORC1-ULK1 signalling axis drives the initial steps of autophagy induction. We conclude with a summary of our growing appreciation of the additional cellular pathways that interconnect with the core mTORC1-ULK1 signalling module.

Author(s):Gallagher, Laura E and Chan, Edmond Y W
Item type:Article
ID code:49427
Keywords:animals, autophagy, homeostasis, humans, signal transduction, Pharmacy and materia medica, Biochemistry
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:30 Sep 2014 14:22
Last modified:18 Jan 2019 03:30
URI:https://strathprints.strath.ac.uk/id/eprint/49427
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