Putting the squeeze on mephedrone hydrogen sulfate
Satthaphut, Natsiri and Sutcliffe, Oliver B. and Oswald, Iain D. H. (2014) Putting the squeeze on mephedrone hydrogen sulfate. Zeitschrift fur Kristallografie, 229 (2). pp. 101-111. ISSN 0044-2968 (https://doi.org/10.1515/zkri-2013-1639)
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Abstract
Herein we report the characterisation of a novel salt of the ``legal high'' (+/-)-4'-methylmethcathinone hydrogen sulfate and its polymorphism under ambient and high pressure conditions. Under ambient pressure only one polymorph of the title compound was isolated but when subjected to high pressure a further two polymorphs are observed. The phase transitions at >0.5 GPa and >3.6 GPa are reversible single crystal to single crystal transitions which is possible due to the similarity of the packing in the molecules. It is proposed that these transitions are driven by the pV term of the Gibbs Free Energy equation rather than by the relief of repulsive interactions between molecules.
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Item type: Article ID code: 49237 Dates: DateEventMarch 2014Published5 February 2014Published Online26 June 2013AcceptedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Continuous Manufacturing and Crystallisation (CMAC)Depositing user: Pure Administrator Date deposited: 15 Sep 2014 12:40 Last modified: 29 Jul 2024 00:57 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/49237