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Four new bioactive polybrominated diphenyl ethers of the sponge Dysidea herbacea from West Sumatra, Indonesia

Handayani, D and Edrada-Ebel, Ruangelie and Proksch, P and Wray, V and Witte, L and Van Soest, R W and Kunzmann, A and Soedarsono, [No Value] (1997) Four new bioactive polybrominated diphenyl ethers of the sponge Dysidea herbacea from West Sumatra, Indonesia. Journal of Natural Products, 60 (12). pp. 1313-1316. ISSN 0163-3864

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Abstract

The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2-5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C-1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE +/- 0.19] and 0.94 [SE +/- 0.70] microg/mL, respectively.

Item type: Article
ID code: 48605
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Keywords: animals, artemia, bacillus subtilis, cladosporium, drug screening assays, antitumor, lethal dose 50, magnetic resonance spectroscopy, polybrominated biphenyls, porifera, Therapeutics. Pharmacology, Pharmacy and materia medica, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited: 17 Jun 2014 11:34
Last modified: 22 Feb 2019 03:39
URI: https://strathprints.strath.ac.uk/id/eprint/48605
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