Picture water droplets

Developing mathematical theories of the physical world: Open Access research on fluid dynamics from Strathclyde

Strathprints makes available Open Access scholarly outputs by Strathclyde's Department of Mathematics & Statistics, where continuum mechanics and industrial mathematics is a specialism. Such research seeks to understand fluid dynamics, among many other related areas such as liquid crystals and droplet evaporation.

The Department of Mathematics & Statistics also demonstrates expertise in population modelling & epidemiology, stochastic analysis, applied analysis and scientific computing. Access world leading mathematical and statistical Open Access research!

Explore all Strathclyde Open Access research...

Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species : novel inhibitors of protein kinases

Brauers, Gernot and Edrada-Ebel, Ruangelie and Ebel, Rainer and Proksch, Peter and Wray, Victor and Berg, Albrecht and Gräfe, Udo and Schächtele, Christoph and Totzke, Frank and Finkenzeller, Gunter and Marme, Dieter and Kraus, Jurgen and Münchbach, Miriam and Michel, Manuela and Bringmann, Gerhard and Schaumann, Karsten (2000) Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species : novel inhibitors of protein kinases. Journal of Natural Products, 63 (6). pp. 739-745. ISSN 0163-3864

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

An undescribed fungus of the genus Microsphaeropsis, isolated from the Mediterranean sponge Aplysina aerophoba, produces two new betaenone derivatives (1, 2) and three new 1,3,6, 8-tetrahydroxyanthraquinone congeners (5-7). The structures of the compounds were established on the basis of NMR spectroscopic and mass spectrometric data and by CD spectroscopy. This is the first report wherein the (1)H and (13)C NMR data of the betaenone congeners are fully and unambiguously assigned on the basis of two-dimensional NMR spectroscopy. Furthermore, we describe the first elucidation of the absolute configuration of 1-(2'-anthraquinonyl)ethanols such as 5 and 6, by quantum chemical calculation of their circular dichroism (CD) and comparison with experimentally measured spectra. Moreover, it was shown that compounds 1, 5, 6, and 7 are inhibitors of PKC-epsilon, CDK4, and EGF receptor tyrosine kinases.