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Open Access research which pushes advances in bionanotechnology

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SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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Methoxy-functionalized N-heterocyclic carbenes

Nelson, David J. and Collado, Alba and Manzini, Simone and Meiries, Sebastien and Slawin, Alexandra M Z and Cordes, David B. and Nolan, Steven P. (2014) Methoxy-functionalized N-heterocyclic carbenes. Organometallics, 33 (8). pp. 2048-2058. ISSN 0276-7333

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Abstract

The effect of methoxy functionalization of three N-heterocyclic carbene ligands was assessed using a variety of methods. The steric environment of each carbene has been assessed in various coordination environments. The electronic properties, specifically the electron-donating character and π-accepting ability, have been evaluated using nickel and iridium complexes and selenium adducts, respectively. Comparisons with the parent systems have been made with respect to both electronic and steric properties. The carbenes IPr OMe, SIPrOMe, and IPrOMe have been found to be more electron donating than the parent systems IPr, SIPr, and IPr* and only slightly less π accepting, yet they exhibit similar steric properties.