Biocatalytic amide condensation and gelation controlled by light

Sahoo, Jugal Kishore and Nalluri, Siva Krishna Mohan and Javid, Nadeem and Webb, Hannah and Ulijn, Rein V. (2014) Biocatalytic amide condensation and gelation controlled by light. Chemical Communications, 50 (41). pp. 5462-5464.

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Abstract

We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ formation, by protease catalysed peptide synthesis, of self-assembling trans- in ambient light; however, irradiation with UV light gives rise to the cis-isomer, which readily hydrolyzes to its amino acid derivatives (cis- + ) with consequent gel dissolution.