Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry

Fontanals Torroja, Nuria and Miralles, Núria and Abdullah, Norhayati and Davies, Arlene and Gilart, Núria and Cormack, Peter A.G. (2014) Evaluation of strong cation-exchange polymers for the determination of drugs by solid-phase extraction-liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1343. pp. 55-62. ISSN 0021-9673

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Abstract

This paper presents eight distinct strong cation-exchange resins, all of which were derived from precursor resins that had been synthesised using either precipitation polymerisation or non-aqueous dispersion polymerisation. The precursor resins were transformed into the corresponding strong cation-exchange resins by hypercrosslinking followed by polymer analogous reactions, to yield materials with high specific surface areas and strong cation-exchange character. These novel resins were then evaluated as strong cation-exchange (SCX) sorbents in the solid-phase extraction (SPE) of a group of drugs from aqueous samples. Following preliminary experiments, the two best-performing resins were then evaluated in solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE/LC-MS/MS) to determine a group of drugs from sewage samples. In general, use of these sorbents led to excellent recovery values (75% - 100%) for most of the target drugs and negligible matrix effects (ME) (< 20% ion suppression/enhancement of the analyte signal), when 50 mL and 25 mL of effluent and influent sewage water samples, respectively, were percolated through the resins. Finally, a validated method based on SPE/LC-MS/MS was used to quantify the target drugs present in different sewage samples

ORCID iDs

Fontanals Torroja, Nuria, Miralles, Núria, Abdullah, Norhayati, Davies, Arlene, Gilart, Núria and Cormack, Peter A.G. ORCID logoORCID: https://orcid.org/0000-0002-3390-8176;